Logic therefore dictates that the best option is to have multiple guns stored throughout the house so you can access them rapidly and as the situation changes. Add a good set of night sights so you can aim under both normal lighting an low light conditions. So, given the choices, what should you choose? For these reasons and based on my own research into gun shot victims I advocate the 9mm. Vital organs are only 4" deep on humans, so a large wound which reaches only 6" deep, is deep enough to deliver the pain of a shallow wound, incapacitation of a large wound cavity with the trauma of vital organ damage. Just note that any military lethality data is irrelevant to your needs as a civilian. But neither did the family that was the victim of the Cheshire, CT home invasion murders.
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I never want to be in this situation legally where over penetrating rounds have hit a bystander and have taken measures to reduce that potential situation by selecting low penetration rounds for my handguns carried or used for defense.